Neurotrophic effect of eptide exendin-4 PDF

Exendin-4 isolated from Heloderma suspectum venom acts via glucagon-like peptide 1 (GLP-1) receptor and has clinically been used in the type 2 diabetes. In this study, we investigated the effects of exendin-4 on cell proliferation and neuroblast differentiation in the subgranular zone (SGZ) of the dentate gyrus in mice.

Neuroprotective effect of the glucagon‐like peptide‐1 receptor ... the action of neurotrophic factors and the antiapoptosis pathway in a variety of nerve insults. The objective of the present study was to clarify whether synthetic exendin‐4 had a therapeutic effect against a model of diabetic peripheral neuropathy and to investigate ...